Fluocinolone

Therapeutic Area:

Generic Name:

Fluocinolone

Dosage Form:

ointment

Drug Dose

Therapeutic Indications:

Atopic dermatitis, Corticosteroid-responsive dermatoses, Scalp psoriasis, Seborrheic dermatitis of the scalp

Mechanism of Action:

Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive properties. May depress the formation, release, and activity of endogenous chemical mediators of inflammation, (kinins, histamine, liposomal enzymes, prostaglandins) through the induction of phospholipase A inhibitory proteins (lipocortins) and sequential inhibition of the release of arachidonic acid. Fluocinolone has low to intermediate range potency (dosage-form dependent).

Method of Administration:

Apply sparingly in a thin film; rub in lightly. In hairy sites, the hair should be parted to allow direct contact with the lesion. Occlusive dressings may be helpful in managing psoriasis or recalcitrant conditions, but should not be used if an infection develops.

Notes

Hypersensitivity to fluocinolone or any component of the formulation

Interactions:

Aldesleukin: Corticosteroids may diminish the antineoplastic effect of Aldesleukin. Risk X: Avoid combination

Pregnancy and Lactation:

Pregnant patients should avoid application of topical corticosteroids to areas with high percutaneous absorption (eg, arm pit, skin folds, vulva).

Topical corticosteroids are generally considered acceptable for use in patients who are breastfeeding.

Warning and Precaution:

  • Adrenal suppression: May cause hypercortisolism or suppression of hypothalamic-pituitary-adrenal (HPA) axis, particularly in younger children or in patients receiving high doses for prolonged periods. HPA axis suppression may lead to adrenal crisis.
  • Contact dermatitis: Allergic contact dermatitis can occur; it is usually diagnosed by failure to heal rather than clinical exacerbation.

Adverse Reactions:

Acneiform eruptions, allergic contact dermatitis, atopic dermatitis (secondary), burning, dryness, erythema, folliculitis, irritation, itching, hypertrichosis, hypopigmentation, keratosis pilaris, miliaria, papules, perioral dermatitis, pustules, shiny skin, skin atrophy, striae

Storage:

Store below 30ºC and protect from freezing.