Lidocaine-H

Therapeutic Area:

Generic Name:

Lidocaine-H

Dosage Form:

cream and ointment

Drug Dose

Therapeutic Indications:

Anti-inflammatory/anesthetic: Topical relief of pruritus, pruritic eczemas, abrasions, minor burns, radiation burns, inflammatory skin conditions, sun exposure, insect bites; pain, itching, soreness, and discomfort due to hemorrhoids, anal fissures, pruritus ani, pruritus vulvae, and similar conditions of the skin and mucous membranes.

Mechanism of Action:

Lidocaine: Blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membrane’s permeability to sodium ions, which results in inhibition of depolarization with resultant blockade of conduction.

Hydrocortisone: Topical corticosteroids have anti-inflammatory, antipruritic, and vasoconstrictive properties

Method of Administration:

Topical: Apply thin film to affected area.

Notes

Hypersensitivity to lidocaine, hydrocortisone, local anesthetics of the amide type, corticosteroids, or any component of the formulation; tuberculous or fungal lesions; skin vaccinia, varicella, and acute herpes simplex infections.

Interactions:

Antiarrhythmic Agents (Class IB): Lidocaine (Topical) may enhance the adverse/toxic effect of Antiarrhythmic Agents (Class IB). Risk C: Monitor therapy

Antiarrhythmic Agents (Class III): Lidocaine (Topical) may enhance the arrhythmogenic effect of Antiarrhythmic Agents (Class III). Antiarrhythmic Agents (Class III) may increase the serum concentration of Lidocaine (Topical). This mechanism specifically applies to amiodarone and dronedarone. Risk C: Monitor therapy

Pregnancy and Lactation:

Animal reproduction studies have not been conducted with this combination.

Use with caution in breast-feeding.

Warning and Precaution:

  • Contact dermatitis: Allergic contact dermatitis may occur; it is usually diagnosed by failure to heal rather than clinical exacerbation.
  • Hypersensitivity: Allergic and anaphylactic reactions may occur. Patients allergic to paraaminobenzoic acid derivatives (eg, procaine, tetracaine, benzocaine) have not shown cross sensitivity to lidocaine; use with caution in patients with a history of drug sensitivities.
  • Kaposi sarcoma: Prolonged treatment with corticosteroids has been associated with the development of Kaposi sarcoma (case reports); if noted, discontinuation of therapy should be considered.
  • Local effects: Irritation, sensitivity, and/or infection may occur at the site of application; discontinue use and institute appropriate therapy if local effects occur.

Adverse Reactions:

Acneiform eruption, atrophic striae, burning sensation of skin, folliculitis, hypertrichosis, hypopigmentation, maceration of the skin, miliaria, perioral dermatitis, pruritus, secondary skin infection, skin atrophy, skin irritation, xeroderma

Storage:

Store below 30ºC and protect from freezing.